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1

Loss-of-function PCSK9 mutants evade the unfolded protein response sensor, GRP78, and fail to induce endoplasmic reticulum stress when retained

Lebeau, Paul, Platko, Khrystyna, Al-Hashimi, Ali A, Byun, Jae Hyun, Lhoták, Šárka, Holzapfel, Nicholas, Gyulay, Gabriel, Igdoura, Suleiman A., Cool, David, Trigatti, Bernardo, Seidah, Nabil G., Austin

Journal:

Journal of Biological Chemistry

Year:

2018

Language:

english

File:

PDF, 3.36 MB

english, 2018

2

The effect of pomegranate extract on coronary artery atherosclerosis in SR-BI/APOE double knockout mice

Al-Jarallah, Aishah, Igdoura, Fatima, Zhang, Yi, Tenedero, Christine B., White, Elizabeth J., MacDonald, Melissa E., Igdoura, Suleiman A., Trigatti, Bernardo L.

Journal:

Atherosclerosis

Year:

2013

Language:

english

File:

PDF, 1.82 MB

english, 2013

3

Functional rescue of vitamin C synthesis deficiency in human cells using adenoviral-based expression of murine l-gulono-γ-lactone oxidase

Michael N Ha, Frank L Graham, Chantalle K D'Souza, William J Muller, Suleiman A Igdoura, Herb E Schellhorn

Journal:

Year:

2004

Language:

english

File:

PDF, 810 KB

english, 2004

4

Nonciliated cells of the rat efferent ducts endocytose testicular sulfated glycoprotein-1 (SGP-1) and synthesize SGP-1 derived saposins

S. A. Igdoura, L. Hermo, A. Rosenthal, C. R. Morales

Journal:

The Anatomical Record Advances in Integrative Anatomy and Evolutionary Biology

Year:

1993

Language:

english

File:

PDF, 1.68 MB

english, 1993

5

Five novel mutations in the lysosomal sialidase gene (NEU1) in type II sialidosis patients and assessment of their impact on enzyme activity and intracellular targeting using adenovirus-mediated expression

Susan Pattison, Michael Pankarican, C. Anthony Rupar, Frank L. Graham, Suleiman A. Igdoura

Journal:

Year:

2004

Language:

english

File:

PDF, 268 KB

english, 2004

6

Sulfated glycoprotein-2 synthesized by nonciliated cells of the efferent ducts is targeted to the lysosomal compartment

S. A. Igdoura, L. Hermo, C. R. Morales

Journal:

Microscopy Research and Technique

Year:

1994

Language:

english

File:

PDF, 1.41 MB

english, 1994

7

Hormonal regulation of sulfated glycoprotein-1 synthesis by nonciliated cells of the efferent ducts of adult rats

A. L. Rosenthal, S. A. Igdoura, C. R. Morales, Dr. L. Hermo

Journal:

Molecular Reproduction and Development

Year:

1995

Language:

english

File:

PDF, 1.65 MB

english, 1995

8

Role of sulfated glycoprotein-1 (SGP-1) in the disposal of residual bodies by sertoli cells of the rat

Suleiman A. Igdoura, Dr. Carlos R. Morales

Journal:

Molecular Reproduction and Development

Year:

1995

Language:

english

File:

PDF, 1.38 MB

english, 1995

9

Targeting of endogenous sulfated glycoprotein-1 and -2 to lysosomes within nonciliated cells of the efferent ducts during postnatal development of the rat

Dr. L. Hermo, A. L. Rosenthal, S. A. Igdoura, C. R. Morales

Journal:

Molecular Reproduction and Development

Year:

1995

Language:

english

File:

PDF, 1.25 MB

english, 1995

10

Cloning, expression and chromosomal mapping of human lysosomal sialidase and characterization of mutations in sialidosis

Pshezhetsky, Alexey V., Richard, Catherine, Michaud, Lorraine, Igdoura, Suleiman, Wang, Shupei, Elsliger, Marc-André, Qu, Jingyi, Leclerc, Daniel, Gravel, Roy, Dallaire, Louis

Journal:

Nature Genetics

Year:

1997

File:

PDF, 620 KB

1997

11

Ultrastructural and immunocytochemical study of skin fibroblasts from normal and sialidosis patients

S. Igdoura, C. Morales, J. Tranchemontagne, M. Potier

Journal:

Cell and Tissue Research

Year:

1994

Language:

english

File:

PDF, 3.27 MB

english, 1994

12

Trafficking of sulfated glycoprotein-1 (prosaposin) to lysosomes or to the extracellular space in rat Sertoli cells

Suleiman A. Igdoura, Adam Rasky, Carlos R. Morales

Journal:

Cell and Tissue Research

Year:

1996

Language:

english

File:

PDF, 659 KB

english, 1996

13

Late onset Tay–Sachs disease in mice with targeted disruption of the Hexa gene: behavioral changes and pathology of the central nervous system

Elena I Miklyaeva, Weijia Dong, Alexandre Bureau, Roya Fattahie, Yongqin Xu, Meng Su, Gordon H Fick, Jing-Qi Huang, Suleiman Igdoura, Nobuo Hanai, Roy A Gravel

Journal:

Year:

2004

Language:

english

File:

PDF, 1.17 MB

english, 2004

14

α-Mannosidases involved in N-glycan processing show cell specificity and distinct subcompartmentalization within the Golgi apparatus of cells in the testis and epididymis

Suleiman A. Igdoura, Annette Herscovics, Anita Lal, Kelley W. Moremen, Carlos R. Morales, Louis Hermo

Journal:

European Journal of Cell Biology

Year:

1999

Language:

english

File:

PDF, 6.62 MB

english, 1999

15

A point mutation in the neu1 promoter recruits an ectopic repressor, Nkx3.2 and results in a mouse model of sialidase deficiency

Marc J. Champigny, Mark Mitchell, Alison Fox-Robichaud, Bernardo L. Trigatti, Suleiman A. Igdoura

Journal:

Molecular Genetics and Metabolism

Year:

2009

Language:

english

File:

PDF, 2.04 MB

english, 2009

16

69. The therapeutic potential of small pharmacological molecules in the treatment of Sialidosis

Erin M. O’Leary, Suleiman A. Igdoura

Journal:

Molecular Genetics and Metabolism

Year:

2010

Language:

english

File:

PDF, 42 KB

english, 2010

17

67. Immune cell phenotypes and cytokine response in a mouse model of sialidase deficiency

Suleiman Igdoura, Elizabeth White, Abraham Yang, Bernardo Trigatti, Suleiman Igdoura

Journal:

Molecular Genetics and Metabolism

Year:

2010

Language:

english

File:

PDF, 42 KB

english, 2010

18

68. Impact of tumor necrosis factor-alpha deletion on astrolgliosis and microgliosis in the CNS of Sandhoff mice

Suleiman Igdoura, Alex Hooper, Hatim Abou-ouf, Michael Randazzo, Bernardo Trigatti

Journal:

Molecular Genetics and Metabolism

Year:

2010

Language:

english

File:

PDF, 42 KB

english, 2010

19

Transcriptional induction of human lysosomal sialidase promoter as a potential strategy for the treatment of Tay Sachs disease

Suleiman Igdoura, Matthew Johnson, David Egier

Journal:

Molecular Genetics and Metabolism

Year:

2011

Language:

english

File:

PDF, 57 KB

english, 2011

20

Characterization of the mouse lysosomal sialidase promoter

Marc J. Champigny, Matthew Johnson, Suleiman A. Igdoura

Journal:

Year:

2003

Language:

english

File:

PDF, 1.22 MB

english, 2003

21

Overexpression of MyoD-inducible lysosomal sialidase (neu1) inhibits myogenesis in C2C12 cells

Marc J. Champigny, Robert Perry, Michael Rudnicki, Suleiman A. Igdoura

Journal:

Experimental Cell Research

Year:

2005

Language:

english

File:

PDF, 636 KB

english, 2005

22

The therapeutic potential of pharmacological chaperones and proteosomal inhibitors, Celastrol and MG132 in the treatment of sialidosis

Erin M. O'Leary, Suleiman A. Igdoura

Journal:

Molecular Genetics and Metabolism

Year:

2012

Language:

english

File:

PDF, 1.38 MB

english, 2012

23

PO22-699 PREVENTION OF ATHEROSCLEROSIS IN APOE KNOCKOUT MICE USING SIALIDASE INHIBITORS: A NEW CLASS OF ANTI-ATHEROGENIC DRUGS

Igdoura, S.A., Yang, A., DeSA, D., Trigatti, B.L.

Journal:

Atherosclerosis Supplements

Year:

2007

Language:

english

File:

PDF, 79 KB

english, 2007

24

Suppression of Spermatogenesis by Low-Level Glycerol Treatment

SULEIMAN A. IGDOURA, Dr. JOHN P. WIEBE

Journal:

Journal of Andrology

Year:

1994

Language:

english

File:

PDF, 1.83 MB

english, 1994

25

Low Density Lipoprotein Receptor-Related Protein-1 Expression in the Testis: Regulated Expression in Sertoli Cells

SULEIMAN A. IGDOURA, W. SCOTT ARGRAVES, Dr. CARLOS R. MORALES

Journal:

Journal of Andrology

Year:

1997

Language:

english

File:

PDF, 2.58 MB

english, 1997

26

Th-W60:6 Tissue-specific sialidase deficiency protects against atherosclerosis in experimental animals

Yang, A.E., Tedesco, V., Kufaishi, H.F., Trigatti, B.L., Igdoura, S.A.

Journal:

Atherosclerosis Supplements

Year:

2006

Language:

english

File:

PDF, 140 KB

english, 2006

27

The Effects of Diet on Occlusive Coronary Artery Atherosclerosis and Myocardial Infarction in Scavenger Receptor Class B, Type 1/Low-Density Lipoprotein Receptor Double Knockout Mice

Fuller, M., Dadoo, O., Serkis, V., Abutouk, D., MacDonald, M., Dhingani, N., Macri, J., Igdoura, S. A., Trigatti, B. L.

Journal:

Arteriosclerosis Thrombosis and Vascular Biology

Year:

2014

Language:

english

File:

PDF, 2.19 MB

english, 2014

28

Miglustat as a therapeutic agent: prospects and caveats

Venier, R. E., Igdoura, S. A.

Journal:

Journal of Medical Genetics

Year:

2012

Language:

english

File:

PDF, 239 KB

english, 2012

29

Transient neonatal hyperparathyroidism: a presenting feature of sialidosis type II

Eminoglu, Tuba Fatma, Özkan, Mehpare, Igdoura, Suleiman, Dursun, Arzu, Zenciroğlu, Ayşegül

Journal:

Journal of Pediatric Endocrinology and Metabolism

Year:

2013

Language:

english

File:

PDF, 253 KB

english, 2013

30

Lysosomal and Proteasomal Degradation Play Distinct Roles in the Life Cycle of Cx43 in Gap Junctional Intercellular Communication-deficient and -competent Breast Tumor Cells

Qin, H., Shao, Q., Igdoura, S. A., Alaoui-Jamali, M. A., Laird, D. W.

Journal:

Journal of Biological Chemistry

Year:

2003

Language:

english

File:

PDF, 1.33 MB

english, 2003

31

Dramatically Different Phenotypes in Mouse Models of Human Tay-Sachs and Sandhoff Diseases

Phaneuf, D., Wakamatsu, N., Huang, J.-Q., Borowski, A., Peterson, A. C., Fortunato, S. R., Ritter, G., Igdoura, S. A., Morales, C. R., Benoit, G., Akerman, B. R., Leclerc, D., Hanai, N., Marth, J. D.,

Journal:

Human Molecular Genetics

Year:

1996

Language:

english

File:

PDF, 566 KB

english, 1996

32

Sialidase-mediated depletion of GM2 ganglioside in Tay-Sachs neuroglia cells

Journal:

Human Molecular Genetics

Year:

1999

Language:

english

File:

PDF, 189 KB

english, 1999

33

Regulation of SR-BI-mediated selective lipid uptake in Chinese hamster ovary-derived cells by protein kinase signaling pathways

Zhang, Y., Ahmed, A. M., McFarlane, N., Capone, C., Boreham, D. R., Truant, R., Igdoura, S. A., Trigatti, B. L.

Journal:

The Journal of Lipid Research

Year:

2006

Language:

english

File:

PDF, 396 KB

english, 2006

34

Cathepsin A Is Expressed in a Cell- and Region-specific Manner in the Testis and Epididymis and Is Not Regulated by Testicular or Pituitary Factors

Luedtke, C. C., Andonian, S., Igdoura, S., Hermo, L.

Journal:

Journal of Histochemistry & Cytochemistry

Year:

2000

Language:

english

File:

PDF, 357 KB

english, 2000

35

Cloning of the cDNA and Gene Encoding Mouse Lysosomal Sialidase and Correction of Sialidase Deficiency in Human Sialidosis and Mouse SM/J Fibroblasts

Igdoura, S. A., Gafuik, C., Mertineit, C., Saberi, F., Pshezhetsky, A. V., Potier, M., Trasler, J. M., Gravel, R. A.

Journal:

Human Molecular Genetics

Year:

1998

Language:

english

File:

PDF, 203 KB

english, 1998

36

Deletion of tumor necrosis factor- ameliorates neurodegeneration in Sandhoff disease mice

Abo-ouf, H., Hooper, A. W. M., White, E. J., van Rensburg, H. J. J., Trigatti, B. L., Igdoura, S. A.

Journal:

Human Molecular Genetics

Year:

2013

Language:

english

File:

PDF, 1.68 MB

english, 2013

37

Hypomorphic sialidase expression decreases serum cholesterol by downregulation of VLDL production in mice

Yang, A., Gyulay, G., Mitchell, M., White, E., Trigatti, B. L., Igdoura, S. A.

Journal:

The Journal of Lipid Research

Year:

2012

Language:

english

File:

PDF, 1.50 MB

english, 2012

38

The inhibition of endocytosis affects HDL-lipid uptake mediated by the human scavenger receptor class B type I

Zhang, Yi, Ahmed, Ayesha M., Tran, Thu L., Lin, Judy, McFarlane, Nicole, Boreham, Douglas R., Igdoura, Suleiman A., Truant, Ray, Trigatti, Bernardo L.

Journal:

Molecular Membrame Biology

Year:

2007

Language:

english

File:

PDF, 2.82 MB

english, 2007

39

Differential expression of cathepsins B and D in testis and epididymis of adult rats.

Igdoura, S. A., Morales, C. R., Hermo, L.

Journal:

Journal of Histochemistry & Cytochemistry

Year:

1995

Language:

english

File:

PDF, 21.54 MB

english, 1995

40

Purification and Partial Characterization of an Autotomy-Promoting Factor from the Sea Star Pycnopodia helianthoides

Philip V. Mladenov, Suleiman Igdoura, Satish Asotra and Robert D. Burke

Journal:

Biological Bulletin

Year:

1989

Language:

english

File:

PDF, 494 KB

english, 1989

41

Expression and tissue distribution of rat sulfated glycoprotein-1 (prosaposin).

Morales, C. R., El-Alfy, M., Zhao, Q., Igdoura, S. A.

Journal:

Journal of Histochemistry & Cytochemistry

Year:

1996

Language:

english

File:

PDF, 23.76 MB

english, 1996

42

Characterization of Proliferating Lesion‐Resident Cells During All Stages of Atherosclerotic Growth

Lhoták, Šárka, Gyulay, Gabriel, Cutz, Jean‐Claude, Al‐Hashimi, Ali, Trigatti, Bernardo L., Richards, Carl D., Igdoura, Suleiman A., Steinberg, Gregory R., Bramson, Jonathan, Ask, Kjetil, Austin, Richa

Journal:

Journal of the American Heart Association

Year:

2016

Language:

english

File:

PDF, 5.16 MB

english, 2016

43

Bi-phasic gliosis drives neuropathology in a Sandhoff disease mouse model

Hooper, Alexander W.M., Igdoura, Suleiman A.

Journal:

Journal of Neuroimmunology

Year:

2016

Language:

english

File:

PDF, 1.48 MB

english, 2016

44

Neuronal pentraxin 1 depletion delays neurodegeneration and extends life in Sandhoff disease mice

Hooper, Alexander W.M., Alamilla, Javier F., Venier, Rosemarie E., Gillespie, Deda C., Igdoura, Suleiman A.

Journal:

Human Molecular Genetics

Year:

2016

Language:

english

File:

PDF, 1.10 MB

english, 2016

45

Suppression of NK and CD8 + T cells reduces astrogliosis but accelerates cerebellar dysfunction and shortens life span in a mouse model of Sandhoff disease

White, Elizabeth J., Trigatti, Bernardo L., Igdoura, Suleiman A.

Journal:

Journal of Neuroimmunology

Year:

2017

Language:

english

File:

PDF, 1.88 MB

english, 2017

46

Asialoglycoprotein receptors as important mediators of plasma lipids and atherosclerosis

Igdoura, Suleiman A.

Journal:

Current Opinion in Lipidology

Year:

2017

Language:

english

File:

PDF, 181 KB

english, 2017

47

SR-BI in Bone Marrow Derived Cells Protects Mice from Diet Induced Coronary Artery Atherosclerosis and Myocardial Infarction

Pei, Ying, Chen, Xing, Aboutouk, Dina, Fuller, Mark T., Dadoo, Omid, Yu, Pei, White, Elizabeth J., Igdoura, Suleiman A., Trigatti, Bernardo L., Schulz, Christian

Journal:

Year:

2013

Language:

english

File:

PDF, 1.08 MB

english, 2013

48

Loss-of-function PCSK9 Mutants Evade the Unfolded Protein Response Sensor, GRP78, and Fail to Induce Endoplasmic Reticulum Stress when Retained

Lebeau, Paul, Platko, Khrystyna, Al-Hashimi, Ali, Byun, Jae Hyun, Lhotak, Sarka, Holzapfel, Nicholas, Gyulay, Gabriel, Igdoura, Suleiman A., Cool, David R., Trigatti, Bernardo, Seidah, Nabil G., Austi

Journal:

Atherosclerosis Supplements

Year:

2018

Language:

english

File:

PDF, 45 KB

english, 2018

49

Encyclopedia of Movement Disorders || Sialidosis

Year:

2010

Language:

english

File:

PDF, 59 KB

english, 2010

50

Sialidase down-regulation reduces non-HDL cholesterol, inhibits leukocyte transmigration and attenuates atherosclerosis in ApoE knockout mice

White, Elizabeth J, Gyulay, Gabriel, Lhoták, Šárka, Szewczyk, Magdalena M., Chong, Taryne, Fuller, Mark T, Dadoo, Omid, Fox-Robichaud, Alison E, Austin, Richard C., Trigatti, Bernardo, Igdoura, Suleim

Journal:

Journal of Biological Chemistry

Year:

2018

Language:

english

File:

PDF, 2.07 MB

english, 2018